WebApr 11, 2024 · 中发表论文，报道一种全新的采用钴(II)催化剂促进的通过烯糖 (glycals)分子参与的C(sp 3)-C(sp 3)偶联反应方法学，进而成功完成一系列2-脱氧-C-糖苷分子的立体选择性构建。 Cobalt(II)-Catalyzed C(sp 3)-C(sp 3) Coupling for the Direct Stereoselective Synthesis of 2-Deoxy-C-glycosides from Glycals Glycals can be formed as pyranose (six-membered) or furanose (five-membered) rings, depending on the monosaccharide used as a starting material to synthesize the glycal. Glycals can also be classified as endo-glycals or exo-glycals. A glycal is an endo-glycal when the double bond is within the ring. If the … See more Glycal is a name for cyclic enol ether derivatives of sugars having a double bond between carbon atoms 1 and 2 of the ring. The term “glycal” should not be used for an unsaturated sugar that has a double bond in any … See more The first glycal was synthesized by Hermann Emil Fischer and Karl Zach in 1913. They synthesized this 1,2-unsaturated sugar from D-glucose and named their … See more The double bond of a glycal allows many other functional groups to be introduced into a monosaccharide. Like an alkene, a glycal can undergo electrophilic addition across the double bond to add in these new atoms such as halogens, epoxides, and nitrogen. The glycal … See more The original Fischer glycal synthesis was the reductive elimination with zinc of a glycosyl halide. This glycosyl halide was formed from a monosaccharide starting material. Some other synthetic routes include: • Ring … See more
2‐Halo Glycals as “Synthon” for 2‐C ... - Wiley Online Library
WebNov 16, 2024 · A new protocol for the synthesis of 2-deoxy-C-aryl-glycosides and 2-deoxy-C-alkyl-glycosides via iridium-catalyzed directed C—H glycosylation with glycals is reported.The method is amenable for both the C 2 C—H glycosylation of indoles and the methyl C—H glycosylation of secondary methyl amines under the control of an N-linked … how many days left until april 14 2022
Ligand‐Controlled Stereoselective Synthesis of 2‐Deoxy ... - Reddit
WebDec 17, 2024 · Glycals are useful building blocks for forming glycosidic bonds. The catalytic glycosylation of glycals with alcohols, which involves the direct addition of hydrogen and an alkoxyl group to an olefinic bond, is the most atom-efficient approach to synthesizing 2-deoxyglycosides. WebOct 18, 2024 · Heterogeneous or homogeneous azidophenylselenylation (APS) of glycals, i. e., reaction of glycals with Ph 2 Se 2, PhI(OAc) 2 and NaN 3 or TMSN 3 as azide radical donors, is a straightforward way to phenyl 2-azido-2-deoxy-1-selenoglycosides that can be directly used as glycosyl donors. However, heterogeneous APS is characterized by … WebFeb 19, 2024 · A nitrogen-centered radical-mediated strategy for preparing 1,2- trans -2-amino-2-deoxyglycosides in one step was established. The cascade amidoglycosylation was initiated by a benzenesulfonimide radical generated from NFSI under the catalytic reduction of TEMPO. The benzenesulfonimide radical was electrophilically added to the glycals, … high speed piston pump