Hulangerin-dta
WebThis may also finally explain why huLangerin-DTA and Langerin-DTR mice have different phenotypes. There is an excellent preview by Shruti Naik that nicely summarizes the work. Toshiro Hirai had his work looking at CD8 T cell competition for TGFβ activation in the skin published in Immunity with a preview by John Chang. WebLangerin + dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and …
Hulangerin-dta
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WebIn the EU, aquaculture ponds cover an area of 360,000 ha and are a crucial part of the rural landscape. As many ecosystem services (e.g., habitats for protected wildlife, nutrient cycling, etc.) are correlated with the proportion of reed beds relative to open-water areas, it is important in environmental studies to be able to accurately estimate the extent and the … WebThe function of Langerin-expressing cells in the steady-state can be examined by using i.p. injection of low amounts of anti-Langerin mAb/antigen conjugates. Since ligation of Langerin does not activate LC and CD103+ DC, this technique assays the effect of antigen presentation of Langerin+ DC in the absence of exogenous adjuvants.
WebAlthough these observations were made in a transgenic mouse (huLangerin-DTA) that is constitutively devoid of LCs, and therefore, consideration must be given to raising the possibility of an altered epidermal or local immune development, it is noteworthy that: (i) no other epidermal abnormalities were noted (e.g. the γδ + DETC population was intact); … WebOne approach to depleting LC is the “huLangerin-DTA” (DTA) strategy and was developed by Dan Kaplan at Yale University. In this strategy, the active subunit of the diphtheria toxin is expressed under the control of the huLangerin promoter, which results in the selective ablation of epidermal langerin+, MHCII+cells [23].
WebUnexpectedly, huLangerin-DTA mice (ΔLC) that lack Langerhans cells (LC) developed increased skin inflammation… Show more Recruitment of innate immune effector cells … Web1 May 2024 · Dendritic cells (DCs) are the major antigen-presenting cells (APCs) responsible for first-line defense against pathogens and are principal coordinators of the innate and adaptive immune response to pathogens. DCs arise from common myeloid progenitors in the bone marrow (BM).
Web(a) Percentage of DC subsets as a frequency of DCs in adult huLangerin-DTA mice at 7 d.p.i. (b) Percentage of CD8+ T cells as a frequency of mononuclear cells in adult huLangerin-DTA mice at 7...
Web1 May 2012 · Langerhans Cells Require MyD88-Dependent Signals for Candida albicans Response but Not for Contact Hypersensitivity or Migration The Journal of Immunology American Association of Immunologists Abstract. Langerhans cells (LC) are a subset of skin-resident dendritic cells (DC) that reside in the epidermis as immature DC, where they … ebay redfield scopesWeb28 Jun 2011 · In corneas from huLangerin-Cre eYFP-flox, eYFP+ cells were detectable in the epithelium but not in the stroma. Conclusions: The normal corneal epithelium is … ebay redhttp://www.dendritics.net/files/documentation/Welty_NE_et_al%2C_Lang%2C_2013.pdf compare the exchange rateWeb19 Sep 2024 · Langerhans cells (LCs) are epidermis-resident antigen-presenting cells that share a common ontogeny with macrophages but function as dendritic cells (DCs). Their … ebay redemptionWebhuLangerin-DTA (right) mice one day prior to skin infection with Calb-Ag. Expression of IFN- and granzyme B was analyzed on OT-I cells (CD8+, ... compared with huLangerin-DTR mice in which there is a 10 fold expansion of I-A -2W1S tetramer positive CD44high cells. b) Cells were also stimulated ex vivo compare the endocrine system to the plantWeb1 May 2012 · MyD88 signaling is required for an Ag-specific Th17 response. (A) Littermate (WT), Langerin-Cre MyD88, and huLangerin-DTA (DTA) mice were skin infected with C. … compare the excel filesWebThe function of Langerin-expressing cells in the steady-state can be examined by using i.p. injection of low amounts of anti-Langerin mAb/antigen conjugates. Since ligation of … ebay redemption code